If broken open the small black granules are visible. The beads do not enlarge in the stomach and the exterior packaging is usually soft and presents little risk of injury of obstruction.Ī: A specific type of prepared charcoal (similar to activated charcoal used in veterinary hospitals) is found in white plastic cylinders inside bags of prepared foodstuffs like dog treats, chews and jerky. If a dye is present, the silica gel will no longer be a clear to white but instead bright orange, blue, pink or green.Ī: No true toxicity risk exists from exposure to silica gel packets. Some silica products are mixed with a moisture indicator, these indicators may be toxic in large doses. Fortunately, silica dust is rarely encountered by our furry friends. In people who are chronically exposed to/inhaling silica, such as a employee in a mine or factory, a progressive debilitating disease called silicosis can develop. The dust from the processing and creation of silica is irritating to the skin, respiratory tract and gastrointestinal tract. Silica gel packets are usually 1 x 2 inches and contain multiple small white, clear or opaque beads inside.Ī: Silica gel is not intended for consumption and therefor receives the label “do not eat”. It is placed in products to control the humidity and prevent degradation. However, one is a potential problem.Ī: Silica is a hard porous gel that is made synthetically and utilized because of its high affinity for water. Fortunately, most are harmless and require minimal or no veterinary care. Chewing up these little forgotten items is a ‘common pastime’ for canines. The purpose of these little packets is to either reduce moisture in the packaging or to absorb oxygen. 2005-149.In most dried food items, medications and even shoeboxes there is a little packet placed there by the manufacturer to maintain freshness. Department of Health and Human Services, Center for Disease Control and Prevention, DHHS (NIOSH). 2014 30:89–100.īarsan ME (2007) NIOSH pocket guide to chemical hazards. Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells. Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months. Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells. In conclusion, notwithstanding the multiple studies published in recent years, unambiguous linking of physico-chemical properties of SiNPs types to toxicity, bioavailability, or human health effects is not yet possible.Īmorphous silica nanoparticles Colloidal Oxidative stress Pyrogenic Stöber Toxicity.Īhamed M. The correlation between in vitro and in vivo toxicity remains less well established mainly due to improper-unrealistic-dosing both in vitro and in vivo. Adverse effects were mainly observed in acutely exposed animals, while no significant signs of toxicity were noted in chronically dosed animals. In vivo, route of administration and physico-chemical properties of SiNPs influences the toxicokinetics. Amorphous SiNPs (particularly colloidal and stöber) induced toxicity via mechanisms similar to crystalline silica. SiNPs synthesized by wet route exhibited noticeably different biological effects compared to thermal route-based SiNPs. Toxicity of SiNPs in vitro is size, dose, and cell type dependent. In this review, scientific papers from 2010 to 2016 were systematically selected and sorted based on in vitro and in vivo studies: to provide an update on SiNPs toxicity and to address the knowledge gaps indicated in the review of Napierska (Part Fibre Toxicol 7:39, 2010). Large-scale production and use of amorphous silica nanoparticles (SiNPs) have increased the risk of human exposure to SiNPs, while their health effects remain unclear.
0 Comments
Leave a Reply. |